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The crash happened in the 700 block of Old Trail Road in Newberry Township shortly after 9 a.m., according to Township police.
The Township police department's preliminary investigations show a 2017 Toyota Corolla was speeding southbound when it crossed into the northbound lane and struck a 2013 Jeep Wrangler.
In addition to the woman from Harrisburg who died at the scene, three other people were hurt and taken to a local hospital, police say.
Which vehicles the people were in was not released, and additional information about the crash was unavailable as of Tuesday around 1:30 p.m.
The road is expected to remain closed between Beinhower and Red Mill roads for several hours, police say.
Anyone with information or who may have witnessed the incident is asked to contact Newberry Township Police at (717)-938-2608.
This is a developing story, following Daily Voice for updates.
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